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Hypoxia-inducible factor-1alpha (HIF-1α) is a key molecule that plays an important role in the hypoxic environment and can be regulated by the O2 tension of the alkaline helix-loop-helix PAS heterodimer.HIF1α- is able to attenuate renal tubular cell injury by promoting mitophagy in the HG milieu (66)

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They also found better tolerance to movement and less irritation after loading a joint or muscle